Hin received his B.Sc. in Biochemistry and his M.Phil. in Biomedical Sciences from the Chinese University of Hong Kong. He has joined Dr. Yuen’s lab since 2013, working on centromeric RNA in point centromere. His research interests are cell division, chromosome segregation, epigenetics and cell cycle. He likes card magic, photography, basketball, fitness and nutrition.
Dr. Yick Hin LING
Postdoctoral fellow
William is now working on elucidating the cellular mechanism of de novo centromere formation using C. elegans's embryo. The cellular mechanism of chromosome organization and DNA replication also interest him a lot.
He likes outdoor activities, such as cycling, hiking, swimming and diving. He usually hikes from HKU’s campus to Victoria Peak in the weekend. And if you also like diving, he would be excited to team up with you and have a decent diving at Sai Kung.
William ZY LIN, PhD
Postdoctoral fellow
Charmaine started working in the lab as an undergraduate B.Sc student majoring in biotechnology. She then found her interest in studying C. elegans so she decided to pursue her Ph.D under the supervision of Dr. Yuen. Currently, she is interested in understanding how the centromeres of C. elegans are organised. She is now elucidating the role of CSR-1 RNAi pathway on the centromere organization and structure. Besides work, Charmaine also live a very active life. She like playing racket sports (badminton & squash), hiking, food hunting and walking her dogs.
Charmaine WONG, Ph.D.
Postdoctoral fellow
Prior to joining the lab, Phyllis completed her M.S. at the Chinese University of Hong Kong and then worked at BGI-Hong Kong, with the main duty of Exon-sequencing and cancer genotyping. Her current research goals include deciphering the role of histone modifications in neocentromere formation and analyze the dynamic changes of histone modifications during neocentromere formation in holocentric Caenorhabditis elegans. To address these questions, she is using C. elegans artificial chromosomes as a robust system to study new centromere formation especially tracing the histone modification changes in the course of new centromere establishment.
Phyllis Jing ZHU
Ph.D. candidate
Jason received his BSc in Molecular Biology & Biotechnology and Biochemistry from The University of Hong Kong. He has a keen interest in chromosome instability and its prevalence in cancer. Hoping to study its molecular mechanisms with greater detail, he has joined Dr. Yuen's lab since his final-year undergraduate studies in 2015.
Currently, he is conducting proteomic studies on histone chaperone LIN-53 in Caenorhabditis elegans. His research interest lies on the epigenetics of holocentromere formation and ab initio nucleosome assembly. In his spare time, he loves cycling, hiking and not to mention, playing Erhu! See if you can spot him on the street playing this exquisite Chinese instrument!
Jason MAK
M.Phil. candidate
Eric graduated with a MSc degree in Biotechnology from the Hong Kong University of Science and Technology in 2018. He first developed an interest in chromosomal condensation and segregation, during which he investigated the function of condensin complex in dinoflagellates chromosome as his MSc project. To delve into the field of the chromosome, Eric has been a member of Dr. YUEN’s lab for his Ph.D. studies. He has a great passion on the chromosome instability (CIN), particularly on how does the mechanism of merotelic attachment arise biologically. Besides, when Eric is not doing the labwork, he enjoys swimming, playing badminton, and food exploration.
Eric WANG
Ph.D. candidate
Jenny is now a PhD candidate in the lab. Before joining the lab, she received her M.S. from Biomedical Engineering in The Hong Kong Polytechnic University.
She is currently working on the effects of anoxia on cellular mechanisms.
She loves literature (especially French literature), piano music and sports (swimming, aerobics and taekwondo).
Jenny ZHU
Ph.D. candidate
Technician:
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Abby Mak (ascmak@hku.hk)
Undergraduates:​
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Audrey Wu, Intern, 2019
Alumni:
Post-graduates & Post-docs: ​
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Wei Zhang, PhD Student, 2012-2016; Postdoctoral Fellow, 2016-2018
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Sophia Lam, Postdoctoral Fellow, 2017-2018
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Kevin Cheng, MPhil Student, 2013-2015; Currently: Research Assistant, the Centre for Genomics & Child Health, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London
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Bernard Lee, Final Year Project Student, 2011-2012; MPhil Student, 2012-2014; Currently: Research Assistant at Department of Pathology, HKU
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Kyle Law, PDF, 2013-2015
Undergraduates:
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Jasmine Chit Ying Lau, Student Volunteer, 2018
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Keith Yip, Summer Research Fellowship Student, 2018
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Judith Junran Yan, University Research Fellowship Student, Final Year Project Student, 2017-2018
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Crystal Tang, Final Year Project Student, 2017-2018
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Winsum Wing Sum Chan, Final Year Project Student, 2017-2018
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Clarissa Linardi, Part-time Research Assistant, 2017-2018
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Raissa Regina Ng, Internship Student, 2018, Summer Research Fellowship Student, 2017
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Joe Kai Ching Lam, Summer Research Fellowship Student, 2017
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Katie Chin Ching Tsoi (Imperial College London), Summer Volunteer, 2017
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Gami Lok Yee Hiok, Part-time Research Assistant, 2016-2017
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Scarlet Tsz Hing Cho, Directed Study Student, 2016-2017
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Marvin Yu Cheng, Directed Study Student, 2016-2017
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Trupti Naik, Summer Internship Student, 2016
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Monique Lai, Part-time Research Assistant, 2014-2015; Currently: Research assistant, School of Nursing, Polytechnic University
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Amy Wu, Summer Research Fellowship Student, 2013; Final Year Project Student, 2014-2015; Currently: MSc student, Columbia University Mailman School of Public Health
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Clarence Yeung (University of British Columbia), Summer Student Research Assistant, 2014
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Rachel Chan (McGill University), Summer Student Research Assistant
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Ken Cho, Undergraduate Volunteer, 2013-2014; Currently: Research Assistant, Department of Computing Science, HKU
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Yorky Wong, Final Year Project Student, 2012-2013
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Leo Lao, Summer Internship Student, 2012
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Disha Parikh, Summer Helper, 2012; Directed Study Student, 2012-2013;
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Anjana Kulasekara, Summer Research Fellowship Student, 2012
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Horace Chan, Directed Study Student, 2011-2012
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Frank Ye, Undergraduate Volunteer, 2011-2012; Currently PhD student at the Genome Science and Technology (GSAT) program, University of British Columbia, Canada
Research Opportunities:
We are seeking enthusiastic and motivated members to join our team as:
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Post-doctoral fellows;
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PhD and MPhil students;
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NEW: HKU - U of Toronto joint PhD candidate (co-supervised with Dr. Julie Claycomb, Department of Molecular Genetics, University of Toronto), focusing on: Gene Regulation and Epigenetics (including, but not limited to: histone modifications, small RNA pathways, and environmental influences on transgenerational inheritance) and utilizing interdisciplinary approaches, including Developmental and Cell Biology, Genetics, Biochemistry and Molecular Biology in the model nematode C. elegans.
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Strong candidates must have a 4-year BSc in Molecular Biology or a related field, with an A- or better average overall. Previous independent research experience is required, and a TOEFL or equivalent score of >93 is necessary for non-native English speakers. Interested candidates should enquire by emailing the faculty members: julie.claycomb@utoronto.ca and kwyyuen@hku.hk.
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Deadline to apply: Sept 31, 2019; Commencing by: Jan 1, 2020.
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For further information, please visit:
http://www.moleculargenetics.utoronto.ca
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Undergraduate students for Final Year Projects, Directed Studies, Summer Research Fellowship and Part-time research assistants.
Experience in molecular biology, microscopy, cell biology, and genetic analysis would be an asset. Interested applicants should send your CV with a description of previous research experience and research interests to Dr. Karen Yuen (kwyyuen@hku.hk).