Research Articles

​

(* These authors contributed equally to the work)

(^ Corresponding author)

​

• Wong YYC, Wang Y, Tsui EHN and Yuen KWY^. Argonaute protein CSR-1 restricts localization of holocentromere protein HCP-3, the C. elegans CENP-A homolog. Journal of Cell Science, 2024. 137 (18): jcs261895. https://doi.org/10.1242/jcs.261895.
   

• Wang Y, Wong YYC, and Yuen KWY^. Aurora B/AIR-2 is required for sister centromere resolution and centromere protein deposition. Journal of Molecular Cell Biology, 2024. https://doi.org/10.1093/jmcb/mjae045.
   

• Jiang L, Wang X, Zhang D, Yuen KWY^ and Tse YC^. RSU-1 regulates the integrity of dense bodies in muscle cells of aging Caenorhabditis elegans. iScience, 2024. 27(6):109854. https://doi.org/10.1016/j.isci.2024.109854.
   

• Lin Z, Xie Y, Nong W, Ren X, Li R, Zhao Z, Hui JH and Yuen KWY^. Formation of artificial chromosomes in Caenorhabditis elegans and analyses of their segregation in mitosis, DNA sequence composition and holocentromere organization. Nucleic Acids Research, 2021, https://doi.org/10.1093/nar/gkab690.  Press release

​

• Lin Z and Yuen KWY^. RbAp46/48LIN-53 and HAT-1 are required for initial CENP-AHCP-3 deposition and de novo centromere formation in Caenorhabditis elegans embryos. Nucleic Acids Research, 2021, https://doi.org/10.1093/nar/gkab217.  Press release​​​

 

• Iannucci A, Cannicci S^, Lin Z, Yuen KWY, Ciofi C, Stanyon R, Fratini S. Cytogenetic of Decapoda Brachyura: testing technical aspects for obtaining metaphase chromosomes in six mangrove crab species. Caryologia. 2020; 73(2):39-49.​​​

​​

• Bao X, Liu Z, Zhang W, Gladysz K, Fung YME, Tian G, Xiong Y, Wong JWH^, Yuen KWY^, Li XD^.Glutarylation of Histone H4 Lysine 91 Regulates Chromatin Dynamics. Mol. Cell, 2019 Nov 21;76(4):660-675.e9. PubMed Abstract.

​

• Ling YH and Yuen KWY^. Point centromere activity requires an optimal level of centromeric non-coding RNA. Current Genetics. 2019. doi.org/10.1007/s00294-019-00988-6. Pubmed Abstract. Full text. 

​

• Ling YH and Yuen KWY^. Point centromere activity requires an optimal level of centromeric non-coding RNA. Proceedings of the National Academy of Sciences of the United States of America. 2019. doi.org/10.1073/pnas.1821384116. Pubmed Abstract. Full text. F1000Prime Recommendation. See video, press conference and media coverage.

 

 

 

 

 

 

 

 

 

 

​​

​

​

• Zhu J*, Cheng K* and Yuen KWY^. Histone H3K9 and H4 Acetylations and Transcription Facilitate the Initial CENP-AHCP−3 Deposition and De Novo Centromere Establishment in Caenorhabditis elegans Artificial Chromosomes. Epigenetics and Chromatin. 2018. 16:11. doi: 10.1186/s13072-018-0185-1. Pubmed Abstract. Full Text.

 

 

 

 

 

 

 

 

 

 

 

• Zhang W, Yeung CHL, Wu L and Yuen KWY^. Bre1 is Required for Sister Chromatid Cohesion Establishment in Saccharomyces cerevisiae. eLife. 2017. 6. pii: e28231. doi: 10.7554/eLife.28231. Pubmed Abstract. Full Text.

 

 

 

 

 

 

 

 

 

 

 

 

 

• Fung RSK, Jin B, He M, Yuen KWY and Wong AOL^. Grass Carp Follisatin: Molecular cloning, Functional characterization, Dopamine D1 regulation at Pituitary level, and implication in growth hormone regulation. Frontiers in Endocrinology. 2017. doi:10.3389/fendo.2017.00211. 
  Pubmed Abstract. Full Text.

 

• Fung RSK, Bai J, Yuen KWY, Wong AOL^. Activin/follistatin system in grass carp pituitary cells: - Regulation by local release of growth hormone and luteinizing hormone and its functional role in growth hormone synthesis and secretion. PLoS One. 2017. doi: 10.1371/journal.pone.0179789. 
  Pubmed Abstract. Full Text.

 

• Lai K, Li J, Chan C, Chan T, Yuen K, Chiu J. Transcriptiomic alterations in Daphnia magna embryos from mothers exposed to hypoxia. Aquatic Toxicology. 2016. 177:454-463. 
  Pubmed Abstract. Full Text.

 

• Lee BCH, Lin Z and Yuen KWY^. RbAp46/48LIN-53 is Required for Holocentromere Assembly in Caenorhabditis elegans. Cell Reports. 2016. 14:1819-1828. doi: 10.1016/j.celrep.2016.01.065
  Pubmed Abstract. Full Text. Cell Reports Facebook Highlight.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

• Han XB, Yuen KWY and Wu SS. Polybrominated diphenyl ethers affect the reproduction and development, and alter the sex ratio of zebrafish (Danio rerio). Environmental Pollution. 2013. 182:120-6. doi: 10.1016/j.envpol.2013.06.045 Full Text. Pubmed Abstract

 

• Gassmann R*, Rechtsteiner A*, Yuen K*, Muroyama A, Egelhofer T, Gaydos L, Barron F, Maddox P, Essex A, Monen J, Ercan S, Lieb JD, Oegema K, Strome S, and Desai A. An Inverse Relationship to Germline Transcription Defines the C. elegans Holocentromere in Progeny. Nature. 2012. 484(7395):534-7 doi:10.1038/nature10973. Pubmed Abstract. Full Text. F1000 Prime Article Recommendation.

​​

• Yuen K, Nabesima K, Oegema K, and Desai A. Rapid De Novo Centromere Formation Occurs Independently of Heterochromatin Protein 1 in C. elegans Embryos. Current Biology. 2011. 21(21):1800-7. doi: 10.1016/j.cub.2011.09.016 Pubmed Abstract. Full Text.

 

• Ben-Aryoa S, Agmon N, Yuen K, Kwok T, McManus K, Kupiec M, and Hieter P. Proteasome Nuclear Activity Affects Chromosome Stability by Controlling the Turnover of DNA Repair Proteins. PLoS Genetics. 2010. 6(2):e1000852. doi: 10.1371/journal.pgen.1000852. Pubmed Abstract. Full Text. PDF.

​

• Barber T*, McManus K*, Yuen K*, Reis M, Parmigiani G, Shen D, Barrett I, Nouhi Y, Spencer F, Markowitz S, Velculescu V, Kinzler K, Vogelstein B, Lengauer C, and Hieter P. Chromatid Cohesion Defects may Underlie Chromosome Instability in Human Colorectal Cancers. Proceedings of the National Academy of Sciences of the United States of America. 2008. 105(9):3443-8. doi: 10.1073/pnas.0712384105 Pubmed Abstract. Full Text.

​

• Yuen K*, Warren C*, Chen O, Kwok T, Hieter P, and Spencer F. Systematic Genome Instability Screens in Yeast and their Potential Relevance to Cancer. Proceedings of the National Academy of Sciences of the United States of America. 2007. 104(10):3925-3930. doi: 10.1073/pnas.0610642104  Pubmed Abstract. Full Text.

 

• Measday V*, Baetz K*, Guzzo J, Yuen K, Kwok T, Sheikh B, Ding H, Ueta R, Hoac T, Cheng B, Pot I, Tong A, Yamaguchi-Iwai Y, Boone C, Hieter P, and Andrews B. Systematic Yeast Synthetic Lethal and Synthetic Dosage Lethal Screens Identify Genes Required for Chromosome Segregation. Proceedings of the National Academy of Sciences of the United States of America. 2005. 102(39):13956-61. doi: 10.1073/pnas.0503504102. Pubmed Abstract. Full Text.